It is generally acknowledged that ER stress and inflammation are two mechanisms that allow tissue and cells to adapt to infections or stress-induced situations, and ER stress inhibitor 4-PBA has been revealed to significantly decrease the levels of anti-dsDNA antibodies and serum TNF-α, as well as the glomerulonephritis score in an experimental murine lupus model [27]. The gene discussed is TNF; the disease is glomerulonephritis.