Consistently, histological analysis of gonadal AT sections revealed that AdipoqCre/+-Atglfl/fl mice maintained a stable average adipocyte size, that is, ~900 μm2, while Atglfl/fl mice experienced a progressive reduction in adipocyte size of up to 75% by day 30 post-infection, showing that adipocyte size reduction is predominantly due to ATGL-dependent lipolysis (Fig. 3b,c). The gene discussed is PNPLA2; the disease is infection.