In our study (Fig. 1), based on the gene expression profiles obtained from the TCGA database and related clinical information, we performed a preliminary analysis of 13 cuproptosis-related genes expressed in HCC and selected liver cancer tissues for experimental validation to screen for the most prognostically significant differentially expressed gene, DLAT, and further explored the potential role of DLAT in HCC. This evidence concerns the gene DLAT and hepatocellular carcinoma.