TXNRD1 and liver cancer: LASSO Cox regression analysis showed that the four genes had the highest predictive value for OS in liver cancer, and according to lambda (Fig. 9A,B), using the following formula to establish a prognostic signature: Risk score = (0.075 × DLAT + 0.223 × GSR + 0.091 × RPE + 0.068 × TXNRD1).