For example, a strict low-carbohydrate diet was associated with an increase in circulating levels of CRP, but not the inflammatory cytokine IL-6, in apparently healthy but overweight participants36, whereas in individuals with T2DM, a 2-year LCHF diet resulted in a significant decrease in CRP levels compared with participants following a high-carbohydrate, low-fat diet37. The gene discussed is IL6; the disease is type 2 diabetes mellitus.