The histone ‘writers’ Suppressor of Zeste 12 (SUZ12) and Embryonic Ectoderm Development (EED), components of PRC, are frequently and mutually exclusively altered by LoF in sporadic cases of malignant peripheral nerve sheath tumour (MPNST), a rare sarcoma arising within peripheral nerves, generally in the presence of driver mutation in Neurofibromatosis type 1 (NF1) [96]. This evidence concerns the gene SUZ12 and malignant peripheral nerve sheath tumor.