PDGFRA and central nervous system cancer: Similarly, H3.3-G34R/V-bearing gliomas were shown to be neuronal malignancies in which interneuron progenitors are stalled in their differentiation trajectory by the oncohistone, and co-option of platelet-derived growth factor-alpha receptor (PDGFRA) signalling further promotes malignant transformation which is associated with astrocytic features [58].