Finally, an oncogenic fusion has been reported in Endometrial Stromal Sarcoma (ESS), where the oncohistone-mimic EZHIP is fused to the member of remodelling complex MBT Domain containing 1 (MBTD1) (MBTD1:EZHIP) [106]: it is therefore intriguing to speculate that impaired K27me3 spreading is also at the basis of this sarcoma. Here, MBTD1 is linked to endometrioid stromal sarcoma.