The mechanisms of action of the brain-restricted H3-K27M mutations also contrasts with the CB-restricted H3-K36 mutations, as these mutations affect the distribution and localisation of the opposing H3K27me3/2 and H3K36me3/2 chromatin marks (see Section “Mechanisms of action of K36 mutations in chondroblastoma”). This evidence concerns the gene KRT36 and chondroblastoma.