CTNNB1 and neoplasm: Tumour initiation and progression can also be sustained in a paracrine manner, as exemplified by the rare tumour craniopharyngioma in which Beta-Catenin-mutant cells form clusters of senescent cells that release Senescence Associated Secretory Phenotype (SASP) factors to stimulate neighbouring unmutated cells to proliferate as a potential non-cell autonomous cancer mechanism [44].