Moreover, germline H3.3-G34R/V mutations cause severe neurodevelopmental defects by decreasing H3K36me3 on H3.3 mutant tail, similarly to its cancer-associated counterpart, impairing recruitment and distribution of DNMT3A and ultimately silencing neuronal genes and activating neuroinflammatory pathways [53] (see also Section “Oncohistones in brain and bone cancer: similarities and differences”). This evidence concerns the gene DNMT3A and bone cancer.