The finding of deletions in the SWI/SNF Related Matrix Associated Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) gene in paediatric rhabdoid tumours has paved the way to the discovery that various components of SWI/SNF chromatin remodelling complexes, including Protein Polybromo-1 (PBRM1) and AT-Rich Interaction Domain 1 A (ARID1A), are among the most common mutations in human cancers [119, 120]. This evidence concerns the gene PBRM1 and cancer.