EZHIP and ependymoma: Recently, Jain et al. demonstrated that molecular mimicry is used by EZH Inhibitory Protein (EZHIP), a molecule normally expressed in the placenta and uniquely upregulated in posterior fossa type A ependymomas where, similarly to H3-K27M, impedes spreading of H3K27me3 by interacting with allosterically activated PRC2 [56].