Smad ubiquitin regulatory factor 2 (SMURF2) is a HECT-type E3 ubiquitin (Ub) ligase that regulates many key functional proteins, including SATB1 [5], RNF20 [6], YY1 [7], and Smad2 [8], which are involved in oncogenic or tumor suppressor functions. This evidence concerns the gene SMURF2 and neoplasm.