NCBI GEO dataset from HCC patients (GSE54238) indicated that ZDHHC23 expression was negatively correlated with PHF2 expression but positively correlated with the expression of SREBF1, its target genes, cell cycle-related genes, and HCC marker genes (Fig. 8a and Supplementary Fig. 12b). Here, PHF2 is linked to hepatocellular carcinoma.