Consistent with these observations, these HFHC-fed Af6LKO mice exhibited decreased serum levels of Asp aminotranferase (AST) and Ala aminotransferase (ALT), as well as a decline in liver fat accumulation and inflammation, compared to NASH Af6flox/flox animals (Fig. 6a–c). The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.