In Ctns KO mice kept under control diet till 8 months-of-age, CC16 urinary concentration reached 1387 ± 128.3 μg/g creatinine, a 21.1-fold higher value than in WT mice (65.7 ± 15.8 μg/g), indicating a moderate Fanconi syndrome. The gene discussed is CTNS; the disease is Fanconi renotubular syndrome.