GPT and metabolic dysfunction-associated steatotic liver disease: Given that a reduction of ALT greater than 17 U/L has been shown to be associated with a histological response in patients with NASH19,39–41, the alterations in serum ALT following a short duration of treatment with ZSP1601 50 mg BID or 100 mg BID could indicate reduced hepatocyte injury and may be clinically relevant to patients with NAFLD.