KRAS and neoplasm: Having used Tuba-seq to uncover differences in the baseline ability of KRAS G12C and KRAS G12D to initiate lung tumors and drive their growth, we next analyzed the impact of inactivating each of the 28 putative tumor suppressor genes on the growth of lung tumors driven by these oncogenes (Fig. 2A, B and Supplementary Fig. 4A).