While the impact of inactivating diverse tumor suppressor genes on KRAS G12D-driven lung cancer growth has been investigated previously19,20, the functional landscape of tumor suppression within KRAS G12C-driven lung cancer in vivo remains entirely uncharacterized, even though KRAS G12C is the most common oncogenic KRAS variant in human lung cancer (Supplementary Fig. 1). This evidence concerns the gene KRAS and lung carcinoma.