While the tumor suppressive effects of inactivating Pten, Rnf43, and Apc are consistent with previous data on these genes and/or related pathways in BRAF-driven lung cancer38,41–43,45–48, the general decreases in magnitude relative to oncogenic KRAS were unexpected (Fig. 4F and Supplementary Fig. 8E). The gene discussed is APC; the disease is neoplasm.