Pathological changes in astrocytes in various models of PTSD are similar to those in models of depression.110 For example, GFAP levels as well as densities of GFAP-positive astrocytic profiles are decreased in a single prolonged stress model of PTSD.428 Astrocytes in experimental PTSD model show significant atrophy with decreased processes complexity and the appearance of fusiform morphotypes.429. Here, GFAP is linked to major depressive disorder.