The onset of the disease is associated with massive dystrophy and death of astrocytes, which directly correlate to the severity of the disease.579,666 Ramified astrocytes with tau depositions in soma and in processes are the histopathological hallmark of the Pick’s disease.667 Global primary tauopathies, characterised by widespread 4-repeat tau inclusions in astrocytes and oligodendrocytes result in dementia dues to neurodegeneration in frontal and temporal lobes.661,668 Finally, ARTAG, which represents a spectrum of age-dependent dementias caused by tau accumulation in astrocytes. This evidence concerns the gene MAPT and Pick disease.