MAOB and Alzheimer disease: Enhancing bioavailability of noradrenaline or adrenergic responsiveness of astrocytes could be a valid therapeutic strategy.541,542 This can be achieved by inhibiting astrocytic MAO-B, and indeed deperenil (aka selegiline) showed some efficacy in improving memory and clinical progression of AD.634 Inhibitors of MAO-B can also reduce hydrogen peroxide production linked to the putrescine catabolism.