GFAP and depressive disorder: Pathological changes in astrocytes in various models of PTSD are similar to those in models of depression.110 For example, GFAP levels as well as densities of GFAP-positive astrocytic profiles are decreased in a single prolonged stress model of PTSD.428 Astrocytes in experimental PTSD model show significant atrophy with decreased processes complexity and the appearance of fusiform morphotypes.429