Pathological astrocytic morphotypes are (i) thorn-shaped astrocytes with tau inclusions in soma and proximal processes, and in the subpial and perivascular endfeet and (ii) granular-fuzzy astrocytes with fine granular tau inclusions mainly in the perinuclear region.662 This latter type of astrocyte was also detected in argyrophilic grain disease, in AD and HD.662. This evidence concerns the gene MAPT and argyrophilic grain disease.