MAPT and Alzheimer disease: Pathological astrocytic morphotypes are (i) thorn-shaped astrocytes with tau inclusions in soma and proximal processes, and in the subpial and perivascular endfeet and (ii) granular-fuzzy astrocytes with fine granular tau inclusions mainly in the perinuclear region.662 This latter type of astrocyte was also detected in argyrophilic grain disease, in AD and HD.662