The presence of both major NSCLC subtypes, ADC and SCC, was confirmed by IHC against the lineage markers TTF-1 (ADC+/SCC−), Krt5 (ADC−/SCC+) and p63 (ADC−/SCC+, Supplementary Fig. 4E–G). This evidence concerns the gene TTF1 and non-small cell lung carcinoma.