IL6 and myocardial infarction: On the other hand, excessive inflammatory reaction may extend ischemic injury by damaging surviving cardiomyocytes of the border zone and promoting protease activity.7 Increased interleukin 6 are associated with poor outcomes in MI patients.8 Pro-inflammatory macrophages impair healing9; whereas suppressing pro-inflammatory macrophage polarization reduces necrosis of cardiomyocytes10 and cardiac rupture11 post-MI.