Card9 depletion decreases angiotensin II-induced cardiac fibrosis,34 prevents pressure overload-induced heart failure and fibrosis,35 and alleviates cardiac injury in obese mice.36 Exploring the function of CARD9 and underlying mechanisms in cardiac injury and remodeling post-MI will provide us the new targets or strategies for MI therapy. Here, CARD9 is linked to myocardial infarction.