CARD9 has been reported to be increased in H9C2 cells and neonatal rat cardiomyocytes treated with hypoxia/reoxygenation or hydrogen peroxide, inhibiting apoptosis and promoting autophagy of cardiomyocytes during myocardial ischemia/reperfusion (I/R).58,59 The differences with our findings may be attributed to the distinct mechanisms of I/R and MI. The gene discussed is CARD9; the disease is myocardial ischemia.