Dectin-1 and Dectin-2, which belong to the CLR family of PRRs, are involved in cardiac ischemia.44,45 We detected an increase in Card9 expression in the myocardium, beginning as early as 1 day after MI, peaking at 3 days, and decreasing thereafter, suggesting that CARD9 is involved in myocardial ischemic injury. This evidence concerns the gene DCLK3 and myocardial ischemia.