CD8A and adenocarcinoma: Moreover, antibody-mediated depletion of Tregs by anti-IL-2Rα antibody did not improve the survival of C57BL/6 mice bearing PK5L1940 adenocarcinoma that were treated with irradiation and PD1-IL2v [10], suggesting that Tregs did not efficiently suppress antitumor CD8+ T cells in response to the excess of exogenous IL-2R agonist.