Furthermore, the expression of N-Cadherin, MMP2, CDK4, and cyclinD1 was significantly elevated, and E-cadherin was inhibited in ccRCC cells that knocked down HOXD3 (Figure 6H), suggesting a tumor-suppressive role for HOXD3 in KIRC tumor. This evidence concerns the gene CDH1 and nonpapillary renal cell carcinoma.