The correlation between HOXD1, HOXD3, and HOXD4 and the OS of patients in pan-cancer was analyzed and found that highly expressed HOXD1 was correlated with short OS in ACC, HNSC, MESO, SARC, and STAD (p < 0.01) (Figure 3A); HOXD3 in ACC, KIRP, LGG, READ, STAD (Figure 3B) (p < 0.01); HOXD4 in ACC, GBM, KIRP, LGG, LUAD, MESO, READ and PRAD (Figure 3C) (p < 0.01). This evidence concerns the gene HOXD4 and cancer.