To investigate the role of HOXD3 in cell proliferation, metastasis, and invasion of ccRCC cells, silenced HOXD3 expression in 786-O and CAKI-1 cells using siRNA, and the HOXD3 expression was tested by qRT-PCR and western blotting (Figure 6A, 6B). Here, HOXD3 is linked to nonpapillary renal cell carcinoma.