Upon examining the BeadChip array data obtained from the livers of WT and Shp−/− mice in this study, we discovered that many genes involved in inflammation and fibrosis were also significantly downregulated in the livers of Shp−/− mice fed WD compared with those of WT counterparts, with significant upregulation of those genes after 6 months of the WD regimen (supplemental Table S1). Here, NR0B2 is linked to Wilson disease.