MYC and familial pancreatic carcinoma: For example, some tumors are highly dependent on OXPHOS for ATP through genetic alterations such as the SMARCA4 mutant lung cancer (29); and the highly bioenergetic reliance on mitochondrial fatty acid oxidation to support tumor growth is found in MYC-overexpressing triple-negative breast cancer (30); as well as high expression of mitochondrial respiratory complex I components is found in pancreatic cancer which has identified as a high OXPHOS tumor (31).