INS and hyperinsulinism: While one previous study24 found that insulin infusion resulted in an increase in frontal NAA/creatine and frontal and temporal Glx/creatine and a decrease in frontal choline/creatine and temporal choline/H2O and myo-inositol/H2O, in our data 2-hours of euglycemic hyperinsulinemia changed only brain myo-inositol concentrations, which were increased during the clamp similarly in lean and obese subjects (Table 3).