In our snRNA-seq dataset, of all tested diseases (59), genes associated with autism (DOID:12849) were overrepresented (Fisher’s exact test, OR = 10.2, Padj = 8.52 × 10−16) among the top 100 Purkinje cell marker genes, including RORA [fold change (FC) = 331.9], AUTS2 (FC = 43.1), and SHANK2 (FC = 13.8) (table S13). The gene discussed is SHANK2; the disease is autism.