To elucidate the consequence of the altered naïve CD8 T cell compartment following sepsis we co-adoptively transferred congenic Ly6C+ and Ly6C- naïve P14 CD8 T cells obtained from sham or CLP donor mice into naïve recipients 1 day before LCMV-Arm infection (Fig 7A). The gene discussed is CD8A; the disease is Sepsis.