Among different types of breast cancer, triple-negative breast cancer (TNBC), one of the breast cancer subtypes with negative expression of progesterone receptor (PR), estrogen receptor (ER), and human epidermal growth factor receptor-2 (HER2), spread quickly to other body regions which has a higher chance of early decline and death than other subtypes of cancer [4]. Here, ESR1 is linked to triple-negative breast carcinoma.