A limitation of Yilmaz and colleagues (2014) [18] towards our understanding into how gut microbiota impact Plasmodium infections and severity of malaria is that the authors did not identify the source of anti-α-gal IgM antibodies in the participants or if the abundance of E. coli O86:B7 in stool is associated with protection against P. falciparum infection. The gene discussed is CD40LG; the disease is malaria.