PI3K/AKT/mTOR signaling may be critical in various solid tumors as it regulates tumor cell growth, chemoresistance, metabolism, and CSC.[32] This study indicates that GAS1 is vital as an ATOH1 transcription target and reduces GCSC activity and chemoresistance via the RET/AKT/mTOR signaling axis. Here, AKT1 is linked to neoplasm.