ATOH1, a member of the bHLH transcription factor family, was initially considered an important regulator of cerebellar granule neuron precursors and cochlear hair cell development.[6, 25] Subsequent studies have indicated that ATOH1 was also implicated in cell proliferation and differentiation.[6, 8] Prior research established intestinal‐specific Atoh1 mouse models and showed that ATOH1 maintained stem cell homeostasis.[26] Although a recent study found that ATOH1 could reduce the proliferation of gastric cancer cells,[27] the mechanism was not explored in depth. This evidence concerns the gene ATOH1 and gastric cancer.