The aim of the study is to evaluate whether there is a correlation between the level of the blood biomarkers studied (SAA, Hcy, S100B, and BDNF) and cognitive scores (MOCA, MIS, FDST, BDST, TMT-A, TMT-B, DSST) in a period of 12-48 months in patients with IBD compared to HC. This evidence concerns the gene BDNF and inflammatory bowel disease.