This wide range of expression was also seen in pretreatment tissue when available (n = 5; mean, 73%; range, 2%-100%); 1 patient who had a complete response in the injected tumor had only 2% TLR4 positivity by immunohistochemical analysis, suggesting response did not depend on tumor TLR4 expression (eFigure 7C in Supplement 2) and instead could be related to TLR signaling by infiltrating immune cells. The gene discussed is TLR4; the disease is neoplasm.