TLR4 and telomere syndrome: We hypothesized that IT GLA-SE with radiotherapy might induce changes in the TCR repertoire within TILs cultured from STS tumors, consistent with an antigen-specific T-cell response.15,16 In this report, we present detailed analysis of the changing TCR repertoire within TILs and in the circulation in the context of a safe, well-tolerated IT TLR4 agonist injection with concurrent radiation.