AR inhibition in prostate cancer has been implicated in G1 arrest (29) while Myc has been shown to regulate the G2–M cell-cycle checkpoint—Myc overexpression diminished ionizing radiation-induced G2–M arrest in mammary epithelial cells (30) and Myc knockdown induced cyclin-dependent kinase 1 and cyclin B1–dependent G2–M arrest in Raji cells (31). The gene discussed is MYC; the disease is prostate cancer.