HDAC9 and prostate adenocarcinoma: These studies also showed that the NEPC cell lines NCI-H660 and LuCaP 173.1CL had lower levels of histone acetylation than the prostate adenocarcinoma cell lines C4-2B and 22Rv1 which may indicate higher levels of HDAC activity (Supplementary Fig. S10I–S1L).