Prostate cancer cell lines, including those lacking AR expression (PC3 and DU145) and those with NE phenotype (MSKCC EF1, NCI-H660), demonstrated IC50s that ranged from 0.82 to 42.2 nmol/L (mean 9.3 nmol/L; Fig. 1A). The gene discussed is AR; the disease is Familial prostate cancer.