SIRPA and cancer: Finally, TNFSF10—TNFRSF10B (TRIAL—TRIAL-R), SIRPA—CD47 (“don't eat me”), C5AR1—RPS19, and GAS6—AXL act as negative regulators of the innate immune system by inhibiting cytokine responses, phagocytosis of cancer cells, and promoting the immunosuppressive TME (Supplementary Table S2).