SPP1 and neoplasm: NRP1/2—VEGFA, SPP1—CD44, SEMA4D—PLXNB2 (CD100—CD72), NRP1—SEMA3A, LRP1—MDK, IGF1—IGF1R, and FPR1/2/3—ANXA1, among others, have been described to trigger the polarization of macrophages toward the M2 immunosuppressive phenotype, and regulate tumor-associated macrophage infiltration into hypoxic tumor regions (Supplementary Table S2).