SPON2 and pneumonia: The network of top 20 differentially expressed genes network also revealed that the expression level of genes between the MRSA-induced pneumonia model and QXWWD (804 mg/kg) group was significantly changed (Fig. 9E), including seven up-regulated genes (Per2, Dbp, Ciart, Zbtb16, Plxna2, Map3k6, and Kcng1) and 13 down-regulated genes (Npas2, Arntl, CYP1a1, Cxcl5, Crabp2, Acan, Ucp1, Spon2, Ereg, NLRP12, Krt6a, Fam124b, and Col10a1).