Importantly, PML association to representative PADs was validated in two additional TNBC cell lines (BT549 and MDA-MB-468 cells, representative of mesenchymal and basal-like 1 subtypes respectively, while MDA-MB-231 cells represent mesenchymal stem-like subtype) (47), while no enrichment over IgG was observed in ER + breast cancer cells MCF7 (Supplementary Figure S2A–D), indicating that PADs are not universal. Here, PML is linked to breast cancer.