We first confirmed downregulation of the most significantly depleted gene of the EMT gene set, the glycoprotein Tenascin-C (Tnc), by qPCR on additional KPC-Sf3b1K700E/+ tumor samples (Figure 2C) and by histology in KPC-Sf3b1K700E/+ PDAC sections (Figure 2D and E). This evidence concerns the gene TNC and neoplasm.