SF3B1 and neoplasm: To rule out that differences in EMT gene expression could be a consequence of differences in the tumor stage between Sf3b1K700E versus Sf3b1 WT KPC tumors, we next established non-cancerous pancreatic organoids from LSL-KrasG12D/+; Trp53fl/fl; Sf3b1flK700E/+ or Sf3b1+/+ and LSL-KrasG12D/+; Trp53fl/fl mice and induced recombination in vitro through lentiviral Cre transduction.