BCL2 and leukemia: Notably, when we further assessed SF3B1K700E dependent alternative splicing of Ppp2r5a, which was reported to impair apoptosis via post-translational modification of BCL2 in leukaemia (Liu et al., 2020a), we did not observe significant alternative 3’ss usage or mRNA expression of Ppp2r5a in KPC-Sf3b1K700E tumor cells (Figure 4—figure supplement 1E, F).