TGFB1 and neoplasm: Importantly, this hypothesis is also supported by previous studies, which demonstrated that SF3B1 mutations induce 3’ missplicing of MAP3K7 in various tumor entities (Bondu et al., 2019; Li et al., 2021; Lieu et al., 2022; Liu et al., 2020b; Wang et al., 2016; Zhang et al., 2019), that aberrant splicing by SF3B1K700E reduces MAP3K7 protein levels (North et al., 2022), and that MAP3K7 mediates TGF-β-induced EMT and apoptosis in mammary epithelial cells (Tripathi et al., 2019).