Since Sf3b1K700E dependent missplicing in MAP3K7 was shown to result in reduced RNA and protein levels of MAP3K7 in leukaemia (North et al., 2022), we hypothesized that the reduced responsiveness to TGF-β signalling in SF3B1K700E mutant pancreas cells is caused by lower MAP3K7 levels. The gene discussed is TGFB1; the disease is leukemia.