EGFR and colorectal cancer: For example, we recently used a mathematical model to identify the mechanism (McFall et al., 2019; McFall et al., 2020; McFall and Stites, 2021) that explains why colorectal cancer patients with a KRAS G13D mutation benefit from treatment with EGFR inhibitors despite KRAS mutations more commonly causing resistance to EGFR inhibitors (De Roock et al., 2010).