PRSS1 is the first gene associated with pancreatitis, and the most common PRSS1 variants, p.R122H and p.N29I, are expected to be penetrant in as high as 90% of the carriers.15 The highest PRSS1 variant frequencies, 31.3% and 30%, were reported in INSPPIRE studies by Giefer et al15 in 240 and Dike et al8 in 333 children patients with RAP/CP respectively, and some smaller studies reported that none of their patients with idiopathic CP or RAP had PRSS1 variations.13PRSS1 variants were defined in 13.4% of our participants, and the most common was p.R122H, consistent with the previous reports. This evidence concerns the gene PRSS1 and pancreatitis.