These results were consistent with previous research remarking that c.180C>T variant is associated with CP, and pancreatitis in general.14, 22 Nevertheless, the variant being more common in the CP than in the RAP + AP group supported the conclusion of LaRusch et al14 that this variant might play a role in disease progression from AP/RAP to CP. The gene discussed is LRPAP1; the disease is alkaline phosphatase measurement.