Aldo-keto reductase 1B10 level is high in non-gastrointestinal solid tumors like liver cancer,7 lung cancer,8 breast cancer,9 and oral squamous cell carcinoma,10 while it is decreased in colorectal cancer,11 which may be caused by the tissue specificity of AKR1B10. Here, AKR1B10 is linked to breast cancer.