Inflammatory biomarkers of severity have been proposed as prognostic factors in sepsis and infections, including C-reactive protein (CRP) (7), erythrocyte sedimentation rate (ESR) (6), neutrophil to lymphocyte ratio (NLR) (8,9), mean platelet volume (MPV) (10), platelet to lymphocyte ratio (PLR) (11), and the systemic immune-inflammation index (SII index) (12). The gene discussed is CRP; the disease is infection.