APOB and cardiovascular disorder: In addition, a few studies on New Zealand rabbits demonstrated that lycopene significantly prevented the risk factors for cardiovascular diseases, including atherosclerosis, by regulating serum lipid profile, improving LDL/HDL ratio, total antioxidant capacity (TAC), and ApoB levels, inhibiting atherosclerotic plaque formation, hepatic HMG‐CoA reductase activities, and reducing ApoA1, IL‐1 and MDA levels (Table 3) (Hu et al., 2008; Lorenz et al., 2012; Verghese et al., 2008).