TNF and neoplasm: In addition, a study on Balb/c mice demonstrated that lycopene could prevent inflammatory response‐mediated prostate cancer progression by lowering tumor volume, tumor Tregs, tumor growth, inhibiting proinflammatory cytokines (IL‐1, IL‐6, IL‐8, and TNF‐α) release, increasing inflammatory tumor cells (Tc1, Th1, Tc17, and Th17 cells), expressions of NK immunity cell marker (CD56+CD16+), macrophage immunity cell marker (F4/80+), and neutrophil immunity cell marker (CD15+CD16+) (Jiang et al., 2018).