Later, it was manifested that lycopene supplementation can significantly decrease the methylation level of GSTP1 in androgen‐independent PC3 cell lines of prostate carcinoma, whereas demethylation of GSTP1 or upregulated GSTP1expressions was not seen when lycopene was supplemented in androgen‐dependent LNCaP cell lines. This evidence concerns the gene GSTP1 and prostate carcinoma.