As demonstrated in an earlier type 2 diabetic wound model (Bitar & Al‐Mulla, 2011), the current results indicated that HFD/STZ‐induced type 2 diabetes leads to irregular Nrf2/Keap1 and Nrf2/HO‐1 signaling by unbalancing GSK‐3β/Fyn/Nrf2 signaling in the liver. Here, KEAP1 is linked to type 2 diabetes mellitus.