In terms of the pathogenic effects of glioma CD44/BSG double-positive EVs, CD44 could interact with hyaluronic acid-rich extracellular matrix, and BSG with MMP14 could promote the proteolytic degradation of ECM components, including laminins and collagens (85), suggesting that this EV could favor cancer invasion and metastasis (55). The gene discussed is CD44; the disease is glioma.