EGFR and central nervous system cancer: For example, mutant EGFRvIII in glioma cells stimulates EGFRvIII-carrying ectosome, termed an oncosome, release with horizontal transfer of oncogenic receptor, which can merge with the plasma membrane in recipient cells lacking EGFRvIII, leading to the activation of EGFR-regulated signaling pathways such as MAPK/ERK (36).