Elevated CD98hc expression was identified as a prognostic marker for predicting a worse prognosis in patients with pulmonary pleomorphic carcinoma (PPC) (148), biliary tract cancer (149), gastric cancer (117), breast cancer (151), CRC (154), HNSCC (37, 152, 153) and pancreatic cancer (39) (Table 3). Here, SLC3A2 is linked to familial pancreatic carcinoma.