MMP-1 is one of the prototypical MMPs and is expressed in a wide variety of tissues in the human body, including the liver, kidney, intestine, stomach, placenta, bladder, and pancreas, in pathological conditions, it increases the bioavailability of insulin-like growth factor-1 (IGF-1), promotes cell proliferation and migration, epithelial regeneration, and inflammation, and has a proteolytic activity that degrades physical barriers and promotes cancer progression (25). This evidence concerns the gene IGF1 and cancer.