In addition, the 1st persistent T2D disease module was enriched with targets of transcription factors, including UBTF, YY1, RUNX1, ZBTB7A, KLF4, RCOR1, GATA1, PBX3, E2F1, and CREB1 (Figure 4B). Here, CREB1 is linked to type 2 diabetes mellitus.