In addition, the 1st persistent T2D disease module was enriched with targets of transcription factors, including UBTF, YY1, RUNX1, ZBTB7A, KLF4, RCOR1, GATA1, PBX3, E2F1, and CREB1 (Figure 4B). This evidence concerns the gene ZBTB7A and type 2 diabetes mellitus.