In addition, the 1st persistent T2D disease module was enriched with targets of transcription factors, including UBTF, YY1, RUNX1, ZBTB7A, KLF4, RCOR1, GATA1, PBX3, E2F1, and CREB1 (Figure 4B). The gene discussed is KLF4; the disease is type 2 diabetes mellitus.