NRP1 and brain disorder: Loading this bullet point of curcumin into exosomes, and then conjugating the exosome membrane with neuropilin-1-targeted peptide (RGERPPR,RGE)neuropilin-1-targeted peptide or the C (rgdyk) peptide had been conjugated to the exosome surface by click chemistry (Jia et al., 2018), will realize the breakthrough blood-brain barrier for the treatment of brain diseases.