Utilizing an unbiased gene array on neuroblastoma cells, Lucas et al. investigated downstream gene targets of PGC-1α in the brain and discovered that PGC-1α overexpression upregulated developmentally relevant genes, including synaptotagmin 2 (syt2), complexin 1 (cplx1), and neurofilament heavy chain (Nefh) expressed in cortical interneuron (Lucas et al., 2014). The gene discussed is CPLX1; the disease is neuroblastoma.