Based on these experimental foundations, we treated HACAT and HSF cell lines with exogenous TNF-α to simulate the localized inflammatory response of epidermal and mesenchymal-derived cells in psoriasis, and analyzed the levels of CXCL8, CCL20, IL1B, IL6, and IL17B expression to assess the extent and status of inflammation. This evidence concerns the gene CXCL8 and psoriasis.