Based on these experimental foundations, we treated HACAT and HSF cell lines with exogenous TNF-α to simulate the localized inflammatory response of epidermal and mesenchymal-derived cells in psoriasis, and analyzed the levels of CXCL8, CCL20, IL1B, IL6, and IL17B expression to assess the extent and status of inflammation. The gene discussed is IL6; the disease is psoriasis.