CALML3-AS1 showed increased expression in the EpD_HF_HairFollicle, EpD_KRT0_StemCyclingKeratinocyte, EpD_KRT1_Basal, EpD_KRT2_ Basalinflammatory, EpD_KRT3_earlySpinous, EpD_KRT4_diffSpinous, EpD_KRT5_Granular and EpD_KRT6_BasalGranular clusters in both normal and psoriasis skin, with significant upregulation observed in psoriasis. The gene discussed is CALML3; the disease is psoriasis.