LCN2 and acute respiratory distress syndrome: Our results showed that genes such as IFN-γ, TNF-α, IL-6, MIP-2, IL-10, KC (CXCL1), CCL-2, MPO, MMP9, TLR2, and LCN2 were significantly upregulated in the lungs of sepsis-induced ARDS mice compared to control mice.