(202) revealed a relationship between TLR4 polymorphism and pan-cancer through an integrated omics approach describing that TLR4 gene expression is remarkably correlated with the expression of DNA methyltransferase 2 (DNMT2) and DNMT3B in the course of skin cutaneous melanoma and stomach adenocarcinoma. The gene discussed is TRDMT1; the disease is cutaneous melanoma.