On the other side, activation of TLR4 stimulated by the LPS has been seen to induce the activation of several vital cancer-critical signaling pathways that include the primary TLR4/NF-κB signaling pathways for inducing anti-apoptotic response and PI3K/Akt signaling pathways for uncontrolled cell division (37, 84). This evidence concerns the gene NFKB1 and cancer.