Considering the metastasis stage, TLR2 triggers the NF-κB activation to signal the induction of the proinflammatory responses and overexpression of type 1 matrix-bound metalloproteinase (MT1-MMP) in microglia thereby activating tumor-released MMP2 that promotes metastasis (60, 61). Here, NFKB1 is linked to neoplasm.