Moreover, this group suggested a potential prognostic role of high expression of TLR9 mRNA in the bone marrow in CLL due to shorter time to first treatment (TTFT) in groups of CLL patients with high TLR9 expression in comparison to low TLR9 expression in bone marrow mononuclear cells (BBMC) (221). Here, TLR9 is linked to B-cell chronic lymphocytic leukemia.