TLR4 and acute lymphoblastic leukemia: In another study, the SNPs analysis on patients with newly diagnosed B-cell acute lymphoblastic leukemia (B-ALL) revealed the role of three specific TLR2 and TLR4 genotypes (TLR-2 Arg753Gln, TLR-4 Thr399Ile, and TLR-4 Asp299Gly) that could predict good B-ALL patients outcome (213).