Notably, TLR4 is highly overexpressed in breast cancer cells and promotes inflammatory response by stimulation from cellular ligands (e.g. HMG1) and results in increased cell proliferation, and lymph node metastasis, regulating the expression of integrin αvβ3 results in the adhesion and invasiveness of metastatic breast cancer cells (108, 109). This evidence concerns the gene HMGB1 and breast cancer.