Expression of the lncRNA HOTAIRM1 (HOXA transcript antisense RNA myeloid 1), known to be involved in transcriptional regulation of the HOXA genes in embryonic and even in cancer stem cells, was shown to be decisive for their proliferation and self-renewal together with the HOTAIRM1 neighboring genes, HOXA1, HOXA2, and HOXA3 (66). The gene discussed is HOTAIRM1; the disease is cancer.