Following exposure to K562 (CML cell line)-derived EVs, T cells demonstrate a phenotypic shift toward an immunosuppressive fate, upregulating signal transducer and activator of transcription 5 (STAT5) signaling whilst decreasing mammalian target of rapamycin – ribosomal s6 kinase (mTOR-S6) signaling leading to a marked Forkhead box P3 (FoxP3) upregulation (73). Here, FOXP3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.