VEGFA and chronic myelogenous leukemia, BCR-ABL1 positive: Wong and colleagues recently demonstrated that K562-derived sEVs carrying the long non-coding RNA LNC000093 and the microRNA miR-675-5p regulate vascular endothelial growth factor (VEGF) expression in BM-MSCs (77), coinciding with the previously described angiogenic ability and high level of VEGF in CML patient plasma that contribute to the tumorigenic niche (78).