Overexpressed miRs in ALL such as miR-146a-5p, miR-181b-5p and miR-199b-3p were shown to functionally bind to TLR8 in hematopoietic cells and BM-MSCs, promoting NF-kB activation and the subsequent secretion of proinflammatory cytokines aiding in the expansion of early hematopoietic cell populations (94). The gene discussed is NFKB1; the disease is acute lymphoblastic leukemia.