Conversely, circular RNAs circ_0009910 (28) and circ_0004136 (29) are both enriched in AML-derived EVs, promote AML malignant cell progression, reduce apoptosis and promote proliferation by acting as sponges for miRs targeting growth factor receptor bound protein 10 (GRB10) and tetraspanin 3 (TSPAN3), respectively (28, 29). This evidence concerns the gene TSPAN3 and acute myeloid leukemia.