Likewise, high levels of miR-10a (130, 131), miR-483 (132) and miR-16 (131) in BM-MSC EVs were linked to increased MM progression, possibly through the regulation of the EPH receptor 8 (EPHA8), insulin-like growth factor 1 receptor/Cyclin D1 (IGF1R/CCND1) axes (131) and tissue inhibitor metalloproteinase 2 (TIMP2) (132). The gene discussed is TIMP2; the disease is Miyoshi myopathy.