Additionally, the enrichment of miR-150 (48), miR-155 (48), miR-584ac (46) and miR-4532 (49) in AML sEVs was linked to the suppression of MYB proto-oncogene (c-MYB), tripartite motif containing 28 (TRIM28) and leucine zipper downregulated in cancer (LDOC1) expression respectively, modulating HSPC hematopoiesis (46, 48, 49). The gene discussed is TRIM28; the disease is cancer.