Additionally, by overlapping the 4,170 DEGs with 38 CRGs, 9 DE-CRGs (MTF1, POLD1, NFE2L2, ACO2, PDHB, DLD, NDUFB2, PLAT, and PDHA1) that differed significantly between the NAFLD and control groups were identified (Figure 2A). The gene discussed is POLD1; the disease is metabolic dysfunction-associated steatotic liver disease.