In IBD fibrotic context, the main pro-EMT cytokines described are Th1, Th2 or Th17 (TGFβ1, TL1A, IL17A, IL13, IL22 and IFNγ), where TGFβ1 is the best characterized pro-EMT agent, capable of triggering the induction of other pro-EMT cytokines. Here, TNFSF15 is linked to inflammatory bowel disease.