In IBD, the high levels of proinflammatory (T helper type 1 (Th1)) cytokines (Tumor necrosis factor alpha (TNFα), Interleukin (IL)1β, and IL6) change the composition of the TJs decreasing transepithelial electrical resistance and amplify mucosal inflammation (Lee, 2015). The gene discussed is TNF; the disease is inflammatory bowel disease.